This study was attempted to assess if obesogenic medications may decrease the effectiveness of lifestyle interventions. Researchers included a total of 5,145 participants with overweight or obese, aged 45 to 76 years with type 2 diabetes. Individuals were allocated randomly to an intervention (vs. support and education). They examined the relationship of exposure to obesogenic medications and successful weight loss (≥ 5% and ≥ 10% of total weight) and fitness gain (≥ 1 and ≥ 2 metabolic equivalents). The outcomes imply that exposure to obesogenic medications could hinder successful weight loss in a lifestyle intervention for people with diabetes.
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